Description

n-[(6S)-8-Fluoro-5,6-Dihydro-4-(1-Methylethyl)-6-[(2S,4R)-Tetrahydro-4-Hydroxy-6-Oxo-2H-Pyran-2-Yl]Benzo[H]Quinazolin-2-Yl]-n-Methylmethanesulfonamide is a high-purity, complex heterocyclic compound featuring a benzo[h]quinazolin core, a fluorinated substituent, and a methanesulfonamide group, making it a critical advanced pharmaceutical intermediate. Its value lies in its precise stereochemistry and functional groups, which are essential for developing targeted therapeutic agents with specific biological activity. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the synthesis and development of novel small-molecule drugs, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), especially for targeted cancer therapies.
• Preclinical & Clinical Research: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and the development of new drug candidates.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control testing of final drug substances.
• Biochemical Research: Utilized as a tool compound in biochemical assays to study enzyme inhibition or receptor binding mechanisms.
• Custom Synthesis: Acts as a starting material for the custom synthesis of more complex, proprietary molecules for specific client research programs.

Basic Information

Product Name	n-[(6S)-8-Fluoro-5,6-Dihydro-4-(1-Methylethyl)-6-[(2S,4R)-Tetrahydro-4-Hydroxy-6-Oxo-2H-Pyran-2-Yl]Benzo[H]Quinazolin-2-Yl]-n-Methylmethanesulfonamide
CAS No.	854898-47-8
Molecular Formula	C24H28FN3O5S
Molecular Weight	489.56 g/mol
Synonyms	8-Fluoro-5,6-dihydro-4-isopropyl-6-[(2S,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]benzo[h]quinazolin-2-yl methyl sulfonamide; (6S)-N-Methyl-8-fluoro-5,6-dihydro-4-(1-methylethyl)-6-[(2S,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]benzo[h]quinazoline-2-sulfonamide; CAS 854898-47-8; Benzo[h]quinazoline-2-sulfonamide derivative; Advanced Pharmaceutical Intermediate 854898-47-8; Fluorinated Quinazoline Sulfonamide
EINECS	Contact for details

Quality Control

Our n-[(6S)-8-Fluoro-5,6-Dihydro-4-(1-Methylethyl)-6-[(2S,4R)-Tetrahydro-4-Hydroxy-6-Oxo-2H-Pyran-2-Yl]Benzo[H]Quinazolin-2-Yl]-n-Methylmethanesulfonamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.