Description

(1,2,4-Triazol-4-Yl) Itraconazole is a key chemical intermediate and derivative of the broad-spectrum antifungal agent itraconazole. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of novel antifungal agents and for structure-activity relationship (SAR) studies. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of itraconazole and its novel analogs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new antifungal compounds with improved efficacy or reduced side effects.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Active Pharmaceutical Ingredient (API) Development: Employed in the research and process development stages for new antifungal API formulations.
• Biochemical Research: Used as a tool compound to study fungal enzyme inhibition and metabolic pathways.

Basic Information

Product Name	(1,2,4-Triazol-4-Yl) Itraconazole
CAS No.	854372-77-3
Molecular Formula	C35H38Cl2N8O4
Molecular Weight	705.64 g/mol
Synonyms	4-(1,2,4-Triazol-4-yl)itraconazole; Itraconazole (1,2,4-triazol-4-yl) derivative; 1,2,4-Triazol-4-yl Itraconazole; Triazolyl Itraconazole; Itraconazole triazole derivative; 4-(4-(4-(4-(((2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1,2,4-triazol-4(1H)-one (long-form IUPAC); Itraconazole Impurity/Intermediate
EINECS	Contact for details

Quality Control

Our (1,2,4-Triazol-4-Yl) Itraconazole is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.