Description

Ropivacaine Mesylate is the mesylate salt form of the long-acting amide-type local anesthetic, ropivacaine. This pharmaceutical intermediate is critical for the formulation of injectable anesthetic solutions, offering a favorable safety profile with reduced cardiotoxicity compared to some analogs. It is primarily utilized by pharmaceutical manufacturers and research organizations in the development and production of regional anesthesia and acute pain management products.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active pharmaceutical ingredient in injectable formulations for local and regional anesthesia.
• Surgical Anesthesia: Used in nerve blocks, epidural anesthesia, and field blocks for various surgical procedures.
• Post-Operative Pain Management: Formulated for continuous epidural infusions or peripheral nerve blocks to manage pain after surgery.
• Obstetric Analgesia: Employed in epidural solutions for labor pain relief.
• Research & Development: Serves as a key reference standard and intermediate in pharmacological studies and new drug development.
• Generic Drug Manufacturing: Essential for companies producing generic versions of ropivacaine-based anesthetic products.

Basic Information

Product Name	Ropivacaine Mesylate
CAS No.	854056-07-8
Molecular Formula	C17H26N2O • CH4O3S
Molecular Weight	370.51 g/mol
Synonyms	(S)-(-)-1-Propyl-2',6'-pipecoloxylidide monomethanesulfonate; (S)-Ropivacaine methanesulfonate; Ropivacaine methanesulphonate; Naropin mesylate; LEVA-101 mesylate; (2S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide methanesulfonate
EINECS	Contact for details

Quality Control

Our Ropivacaine Mesylate is manufactured under strict quality systems. It undergoes rigorous analytical testing to ensure compliance with high-purity standards suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing purity, identity, and impurity profiles. We support compliance with ICH guidelines and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Optical Rotation	-70° to -78° (c=1 in methanol)
Specific Impurity A	≤ 0.3%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.