Description

Dovitinib Dilactic Acid (Tki258 Dilactic Acid) is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) used in advanced research and development. This compound is a potent and selective multi-targeted receptor tyrosine kinase (RTK) inhibitor, primarily targeting VEGFR, FGFR, and PDGFR pathways. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel oncology therapeutics, particularly for renal cell carcinoma and other solid tumors.

Application

• Pharmaceutical API Synthesis: Key intermediate in the commercial-scale production of the anti-cancer drug Dovitinib.
• Oncology Research: Used as a reference standard and active compound in preclinical studies targeting angiogenesis and tumor growth.
• Biochemical Assay Development: Serves as a critical inhibitor in kinase assay kits and high-throughput screening (HTS) platforms.
• Drug Discovery & Development: Employed in structure-activity relationship (SAR) studies and the development of next-generation kinase inhibitors.
• Academic & Institutional Research: Utilized in university and research institute labs for investigating tyrosine kinase signaling pathways.
• GMP Manufacturing: Sourced as a starting material or intermediate for cGMP-compliant manufacturing processes.

Basic Information

Product Name	Dovitinib Dilactic Acid (Tki258 Dilactic Acid)
CAS No.	852433-84-2
Molecular Formula	C23H26FN5O7
Molecular Weight	503.48 g/mol
Synonyms	TKI-258 Dilactic Acid; Dovitinib Dilactate; (3Z,5Z)-3-[(2,4-Dimethyl-1H-pyrrol-5-yl)methylene]-5-(1H-pyrrol-2-ylmethylene)-1-methylpiperidine-2,4-dione Dilactic Acid; TKI258; CHIR-258 Dilactic Acid; 4-Amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one Dilactic Acid
EINECS	Contact for details

Quality Control

Our Dovitinib Dilactic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting high standards for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity (typically >98% by HPLC), related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.