Description

Galeterone is a selective, small-molecule inhibitor of the androgen receptor (AR) and CYP17A1 lyase, representing a significant advancement in targeted cancer therapy research. This compound is crucial for its dual mechanism of action, which disrupts androgen synthesis and signaling, a key pathway in hormone-dependent cancers. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on developing novel treatments for prostate cancer and other androgen-driven malignancies.

Application

• Pharmaceutical Research & Development: As a key investigational new drug (IND) candidate for the treatment of castration-resistant prostate cancer (CRPC).
• Preclinical Studies: Used in in vitro and in vivo models to study androgen receptor degradation and CYP17 inhibition mechanisms.
• Biochemical Assays: Serves as a reference standard and active pharmaceutical ingredient (API) in high-throughput screening and enzyme activity tests.
• Mechanism of Action Research: A vital tool for exploring resistance pathways and combination therapies in oncology.
• Academic Research: Employed in university and institutional labs for fundamental cancer biology and medicinal chemistry projects.
• Drug Formulation Development: Used in early-stage studies for dosage form design, stability testing, and pharmacokinetic profiling.

Basic Information

Product Name	Galeterone
CAS No.	851983-85-2
Molecular Formula	C₂₆H₃₂O₃
Molecular Weight	392.53 g/mol
Synonyms	TOK-001; VN/124-1; 17-(1H-Benzimidazol-1-yl)androsta-5,16-dien-3β-ol; Galeterone (USAN); (3β)-17-(1H-Benzimidazol-1-yl)androsta-5,16-dien-3-ol; AR Degrader; CYP17 Lyase Inhibitor
EINECS	Contact for details

Quality Control

Our Galeterone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research materials. Certificates of Analysis (COA) detailing specifications such as HPLC purity, residual solvents, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.