Description

n-(3-Chloro-4-(3-Fluorobenzyloxy)Phenyl)-6-Iodoquinazolin-4-Amine Dihydrochloride is a high-purity, small molecule chemical intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is primarily utilized by research institutions, pharmaceutical companies, and CROs (Contract Research Organizations) engaged in oncology and precision medicine drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel quinazoline-based kinase inhibitors for targeted cancer therapies.
• Biochemical Research: Used as a reference standard or a tool compound in enzymatic assays and structure-activity relationship (SAR) studies.
• Preclinical Development: Serves as a starting material for the preparation of candidate drug molecules for in vitro and in vivo pharmacological evaluation.
• Academic Research: Employed in university and institutional labs for investigating signal transduction pathways and developing new chemical entities.
• Custom Synthesis: Supplied to fine chemical manufacturers for the production of specialized, non-commercial research compounds under cGMP or non-GMP conditions.

Basic Information

Product Name	n-(3-Chloro-4-(3-Fluorobenzyloxy)Phenyl)-6-Iodoquinazolin-4-Amine Dihydrochloride
CAS No.	851684-46-3
Molecular Formula	C21H15ClFIN3O • 2HCl
Molecular Weight	Contact for details
Synonyms	6-Iodo-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine dihydrochloride; 851684-46-3; UNII-9G3J8X4K8P; 9G3J8X4K8P; BMS-690514 Dihydrochloride; BMS690514 Dihydrochloride; EGFR/VEGFR-2 Inhibitor BMS-690514 Dihydrochloride; n-(3-Chloro-4-(3-Fluorobenzyloxy)Phenyl)-6-Iodoquinazolin-4-Amine 2HCl
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to stringent quality protocols. Each batch is characterized and tested to ensure identity, purity, and consistency, supporting reliable research outcomes. Certificates of Analysis (COA) detailing comprehensive analytical results, including HPLC purity, NMR, and mass spectrometry data, are provided with every shipment. We support development under quality systems appropriate for your stage of research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.