Description

(2E)-2-(1-Methyl-1H-Benzimidazol-2-Yl)-3-[2-(4-Methylpiperazin-1-Yl)-4-Oxo-4H-Pyrido[1,2-A]Pyrimidin-3-Yl]Prop-2-Enenitrile is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel, targeted therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of small-molecule drugs, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Oncology Drug Discovery: Used in the synthesis of potential kinase inhibitors and other targeted cancer therapies due to its benzimidazole and pyridopyrimidine motifs.
• Biochemical Research: Employed as a standard or reagent in structure-activity relationship (SAR) studies and high-throughput screening assays.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry projects and the exploration of novel heterocyclic chemistry.

Basic Information

Product Name	(2E)-2-(1-Methyl-1H-Benzimidazol-2-Yl)-3-[2-(4-Methylpiperazin-1-Yl)-4-Oxo-4H-Pyrido[1,2-A]Pyrimidin-3-Yl]Prop-2-Enenitrile
CAS No.	850738-51-1
Molecular Formula	C24H22N8O
Molecular Weight	438.49 g/mol
Synonyms	850738-51-1; (2E)-2-(1-Methyl-1H-benzimidazol-2-yl)-3-[2-(4-methylpiperazin-1-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]prop-2-enenitrile; 2-(1-Methyl-1H-benzimidazol-2-yl)-3-[2-(4-methyl-1-piperazinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-2-propenenitrile, (2E)-; Prop-2-enenitrile, 2-(1-methyl-1H-benzimidazol-2-yl)-3-[2-(4-methyl-1-piperazinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-, (2E)-
EINECS	Contact for details

Quality Control

Our (2E)-2-(1-Methyl-1H-Benzimidazol-2-Yl)-3-[2-(4-Methylpiperazin-1-Yl)-4-Oxo-4H-Pyrido[1,2-A]Pyrimidin-3-Yl]Prop-2-Enenitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with client specifications and relevant industry guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.