Description

5-[(Z)-(5-Fluoro-1,2-Dihydro-2-Oxo-3H-Indol-3-Ylidene)Methyl]-n-[(2S)-2-Hydroxy-3-(4-Morpholinyl)Propyl]-2,4-Dimethyl-1H-Pyrrole-3-Carboxamide (2Z)-2-Butenedioate is a high-purity, non-racemic chemical intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its complex molecular architecture, which incorporates key pharmacophores including a fluorinated indolinone and a chiral morpholinylpropyl side chain. It is primarily utilized by R&D chemists and process development scientists working in the discovery and synthesis of novel therapeutic agents, particularly within oncology and targeted disease pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Research: Used in the development and optimization of potent and selective kinase inhibitors due to its structural motifs.
• Preclinical Candidate Synthesis: Employed in medicinal chemistry programs for lead optimization and the preparation of compounds for biological screening.
• Process Chemistry & Scale-Up: A key material for developing robust, scalable synthetic routes from laboratory to pilot plant scale.
• Reference Standard: Supplied as a high-purity standard for analytical method development, validation, and quality control in API manufacturing.
• Chemical Biology Probes: Utilized in the design of molecular probes to study specific enzyme functions and cellular signaling pathways.

Basic Information

Product Name	5-[(Z)-(5-Fluoro-1,2-Dihydro-2-Oxo-3H-Indol-3-Ylidene)Methyl]-n-[(2S)-2-Hydroxy-3-(4-Morpholinyl)Propyl]-2,4-Dimethyl-1H-Pyrrole-3-Carboxamide (2Z)-2-Butenedioate
CAS No.	849643-15-8
Molecular Formula	C₂₉H₃₃FN₄O₇
Molecular Weight	568.60 g/mol
Synonyms	SU11274 Fumarate; (2Z)-2-Butenedioic acid compound with 5-[(Z)-(5-fluoro-2-oxo-1H-indol-3(2H)-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1); SU-11274 Fumarate; (Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-N-((2S)-2-hydroxy-3-morpholinopropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide fumarate; SU 11274 Fumarate Salt; Fumaric acid salt of SU11274; Crizotinib intermediate analog fumarate.
EINECS	Contact for details

Quality Control

Our 5-[(Z)-(5-Fluoro-1,2-Dihydro-2-Oxo-3H-Indol-3-Ylidene)Methyl]-n-[(2S)-2-Hydroxy-3-(4-Morpholinyl)Propyl]-2,4-Dimethyl-1H-Pyrrole-3-Carboxamide (2Z)-2-Butenedioate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	Yellow to orange solid powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.