Description

3,4,5-Trifluorophenylacetyl Chloride is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound serves as a key acylating agent, enabling the efficient introduction of the 3,4,5-trifluorophenylacetyl moiety into target molecules. It is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients. Its unique fluorinated structure is critical for modulating the lipophilicity, metabolic stability, and binding affinity of final compounds.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystals used in advanced display technologies.
• Organic Electronics: Employed in the synthesis of fluorinated organic semiconductors and charge-transport materials.
• Peptide Modification: Acts as an acylating agent for the site-specific modification of peptides to improve their pharmacokinetic properties.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D for exploring new fluorinated chemical entities and reaction pathways.

Basic Information

Product Name	3,4,5-Trifluorophenylacetyl Chloride
CAS No.	849623-76-3
Molecular Formula	C8H4ClF3O
Molecular Weight	208.56 g/mol
Synonyms	2-(3,4,5-Trifluorophenyl)acetyl chloride; 3,4,5-Trifluorobenzeneacetyl chloride; (3,4,5-Trifluorophenyl)acetic acid chloride; α-Chloro-3,4,5-trifluoroacetophenone (common misnomer); 3,4,5-Trifluorophenacetyl chloride; TFPA-Cl; 849623-76-3 (CAS Index Name)
EINECS	Contact for details

Quality Control

Our 3,4,5-Trifluorophenylacetyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases, oxidizers, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.