Description

Cevipabulin Fumarate is a high-purity, non-tubulin-binding vascular disrupting agent (VDA) and microtubule inhibitor. This compound is of significant interest in pharmaceutical research and development due to its unique mechanism of action, which targets proliferating endothelial cells in tumor vasculature. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and preclinical evaluation of novel oncology therapeutics, particularly for solid tumors.

Application

• Pharmaceutical Research & Development: As a key active pharmaceutical ingredient (API) intermediate or reference standard in the development of novel anti-cancer drugs.
• Preclinical Oncology Studies: For in vitro and in vivo evaluation of vascular disruption and anti-angiogenic effects in various cancer models.
• Mechanistic Studies: Used in biochemical and cellular assays to study microtubule dynamics and endothelial cell biology.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Drug Discovery Screening: A candidate compound in libraries for high-throughput screening against novel biological targets.

Basic Information

Product Name	Cevipabulin Fumarate
CAS No.	849550-67-0
Molecular Formula	C₂₉H₃₀N₄O₃ • C₄H₄O₄
Molecular Weight	586.63 g/mol
Synonyms	TTI-237; (S)-N-(3-Chloro-4-fluorophenyl)-1-(3-fluoropyridin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide fumarate; TTI 237 Fumarate; Cevipabulin (TTI-237) Fumarate; UNII-6J7C3B4W6N
EINECS	Contact for details

Quality Control

Our Cevipabulin Fumarate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.