Description

Cabozantinib is a potent, orally bioavailable small molecule inhibitor targeting multiple receptor tyrosine kinases, including MET, VEGFR2, and RET. This targeted therapeutic agent is crucial for disrupting key signaling pathways involved in tumor growth, angiogenesis, and metastasis. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of oncology treatments, as well as by advanced research laboratories studying cancer mechanisms.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active pharmaceutical ingredient in formulated anti-cancer medications.
• Oncology Research: A critical tool for in vitro and in vivo studies targeting MET, VEGFR, AXL, and RET signaling pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Drug Development: Used in preclinical and clinical development stages for new therapeutic entities targeting solid tumors.
• Biochemical Assays: Employed in high-throughput screening and biochemical assays to study kinase inhibition and cellular responses.

Basic Information

Product Name	Cabozantinib
CAS No.	849217-68-1
Molecular Formula	C28H24FN3O5
Molecular Weight	501.51 g/mol
Synonyms	Cabozantinib; XL184; BMS-907351; Cometriq®; Cabometyx®; N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; 1,1-Cyclopropanedicarboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-
EINECS	Contact for details

Quality Control

Our Cabozantinib is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical research and development. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and LC-MS. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.