Description

Foretinib (GSK1363089) is a potent, small-molecule inhibitor targeting multiple receptor tyrosine kinases, including MET and VEGFR2. This compound is a critical research tool for investigating signaling pathways involved in tumor growth, angiogenesis, and metastasis. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in oncology drug discovery and preclinical studies.

Application

• Oncology Research: A key reference standard and pharmacological probe for studying MET and VEGFR2 signaling pathways in cancer models.
• Drug Discovery & Development: Used in high-throughput screening, target validation, and as a lead compound for designing novel kinase inhibitors.
• Biochemical Assays: Employed in enzymatic assays to determine inhibitor potency (IC50) and selectivity profiles against various kinases.
• Preclinical Studies: Utilized in cell-based assays and animal models to evaluate antitumor efficacy and mechanisms of action.
• Pharmacology Research: Investigated for its effects on tumor microenvironment, angiogenesis inhibition, and potential combination therapies.
• Reference Material: Serves as a certified standard for analytical method development, quality control, and regulatory submissions.

Basic Information

Product Name	Foretinib (GSK1363089)
CAS No.	849217-64-7
Molecular Formula	C34H34F2N4O6
Molecular Weight	632.65 g/mol
Synonyms	GSK1363089; GSK-1363089; XL880; EXEL-2880; N1-(3-Fluoro-4-((6-methoxy-7-(3-(morpholin-4-yl)propoxy)quinolin-4-yl)oxy)phenyl)-N3-(4-fluorophenyl)-1H-1,2,4-triazole-3,5-diamine; Foretinib free base
EINECS	Contact for details

Quality Control

Our Foretinib (GSK1363089) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. The container should be allowed to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.