Description

2''-Deoxy-Uridine 3'',5''-Bis(o-Phenyl Carbonothioate) is a high-purity, chemically modified nucleoside derivative, specifically engineered as a critical intermediate in advanced pharmaceutical synthesis and oligonucleotide research. Its core value lies in enabling precise chemical modifications for the development of novel therapeutic agents, including antisense oligonucleotides and prodrugs. This compound is essential for research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on cutting-edge nucleic acid chemistry and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of modified nucleoside analogs for antiviral and anticancer drug candidates.
• Oligonucleotide Synthesis: Used in the preparation of modified DNA/RNA strands for antisense therapy, siRNA, and diagnostic probe development.
• Prodrug Development: Serves as a protective group or a functional handle in the design of nucleoside prodrugs to enhance bioavailability and targeting.
• Bioconjugation Chemistry: The carbonothioate groups provide reactive sites for conjugation with targeting ligands, fluorophores, or other bioactive molecules.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies related to nucleic acid metabolism and repair.
• Fine Chemical Synthesis: Acts as a specialized reagent for introducing specific functional groups into complex molecular architectures in medicinal chemistry.

Basic Information

Item	Detail
Product Name	2''-Deoxy-Uridine 3'',5''-Bis(o-Phenyl Carbonothioate)
CAS No.	849104-78-5
Molecular Formula	C24H20N2O7S2
Molecular Weight	512.56 g/mol
Synonyms	2'-Deoxyuridine 3',5'-bis(O-phenyl carbonothioate); 3',5'-Di-O-(phenylcarbonothioyl)-2'-deoxyuridine; dU 3',5'-bis(phenyl thionocarbonate); 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione 3',5'-bis(phenyl thionocarbonate); Deoxyuridine bis(thionocarbonate) derivative
EINECS	Contact for details

Quality Control

Every batch of 2''-Deoxy-Uridine 3'',5''-Bis(o-Phenyl Carbonothioate) is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a Certificate of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and spectroscopic confirmation. Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and GMP-grade production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.