Description

Azd8931 CAS NO 848942-61-0 is a potent and selective small molecule inhibitor targeting the ErbB family of receptor tyrosine kinases, specifically designed to address therapeutic resistance. This compound is of significant interest for its potential in oncology research and development, offering a pathway to overcome limitations of first-generation inhibitors. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on developing next-generation cancer therapeutics.

Application

• Oncology Research & Drug Discovery: A key tool compound for studying ErbB (EGFR/Her2/Her3) signaling pathways and mechanisms of therapeutic resistance in cancer cell lines and animal models.
• Preclinical Development: Used in pharmacokinetic (PK), pharmacodynamic (PD), and toxicology studies to support Investigational New Drug (IND) applications.
• Biochemical Assays: Serves as a reference standard in high-throughput screening (HTS) and enzymatic assays to identify and characterize new ErbB inhibitors.
• Mechanistic Studies: Enables research into the differential inhibition of ErbB receptor dimers and the role of Her3 in signal transduction and resistance.
• Combination Therapy Research: Investigated in conjunction with other chemotherapeutic agents or targeted therapies to enhance efficacy and overcome drug resistance.
• Reference Standard: Used for quality control, method development, and validation in analytical laboratories within the pharmaceutical supply chain.

Basic Information

Product Name	Azd8931
CAS No.	848942-61-0
Molecular Formula	C₂₃H₂₅ClFN₅O₃
Molecular Weight	473.92 g/mol
Synonyms	Sapitinib; AZD-8931; (2S)-1-[4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl]oxy-N-methylpropan-2-amine; AZD 8931; UNII-6K5C8V8QGP; 6K5C8V8QGP; (S)-1-((4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-methylpropan-2-amine
EINECS	Contact for details

Quality Control

Every batch of Azd8931 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) that detail specifications including assay, impurity profile, and chiral purity. Our quality commitment aligns with standards expected for pharmaceutical reference standards and advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥99.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.