Description

5-(4-Methoxy-Phenyl)-7-Trifluoromethyl-Pyrazolo-[1,5-A]Pyrimidine-2-Carbonyl Chloride is a high-value, multi-functional chemical intermediate designed for advanced synthesis. This compound is critical for research and development in pharmaceutical chemistry, where its unique pyrazolopyrimidine core and reactive carbonyl chloride group enable the construction of complex molecular architectures. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs) and other specialized organic compounds.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential drug candidates, particularly those targeting kinase inhibition or other therapeutic pathways.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its heterocyclic structure for biological activity.
• Material Science Precursor: Acts as a precursor for creating specialized organic materials, dyes, or ligands for metal-organic frameworks (MOFs).
• Academic & Contract Research: Essential for medicinal chemistry programs in academic institutions and contract research organizations (CROs) exploring novel heterocyclic compounds.
• Custom Synthesis: Employed by fine chemical suppliers for the custom synthesis of complex molecules for client-specific projects.

Basic Information

Product Name	5-(4-Methoxy-Phenyl)-7-Trifluoromethyl-Pyrazolo-[1,5-A]Pyrimidine-2-Carbonyl Chloride
CAS No.	848422-46-8
Molecular Formula	C15H9ClF3N3O2
Molecular Weight	367.70 g/mol
Synonyms	5-(4-Methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl chloride; 7-Trifluoromethyl-5-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl chloride; Pyrazolo[1,5-a]pyrimidine-2-carbonyl chloride, 5-(4-methoxyphenyl)-7-(trifluoromethyl)-; 848422-46-8; 5-(p-Methoxyphenyl)-7-trifluoromethylpyrazolo[1,5-a]pyrimidine-2-carbonyl chloride
EINECS	Contact for details

Quality Control

Our 5-(4-Methoxy-Phenyl)-7-Trifluoromethyl-Pyrazolo-[1,5-A]Pyrimidine-2-Carbonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We adhere to current Good Manufacturing Practices (cGMP) where applicable for pharmaceutical intermediates. Comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, is performed. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.