Description

1-(Trifluoromethyl)Cyclopropanecarbonyl Chloride is a versatile and highly reactive fluorinated building block essential for advanced organic synthesis. Its unique structure, featuring both a cyclopropane ring and a trifluoromethyl group, makes it a critical intermediate for introducing steric and electronic complexity into target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing drug candidates, particularly those requiring trifluoromethylated cyclopropane motifs to enhance metabolic stability, lipophilicity, and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorinated cyclopropane unit can improve biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for specialty monomers or ligands used in developing polymers and advanced materials with specific surface properties.
• Fluorine Chemistry: An important reagent for academic and industrial research focused on exploring new fluorination methodologies and the properties of fluoroorganic compounds.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the custom synthesis of complex molecules for client projects.

Basic Information

Product Name	1-(Trifluoromethyl)Cyclopropanecarbonyl Chloride
CAS No.	848074-36-2
Molecular Formula	C5H4ClF3O
Molecular Weight	172.53 g/mol
Synonyms	Cyclopropanecarbonyl chloride, 1-(trifluoromethyl)-; 1-(Trifluoromethyl)cyclopropanecarboxylic acid chloride; 1-(Trifluoromethyl)cyclopropanecarboxyl chloride; 1-Trifluoromethylcyclopropanecarbonyl chloride; 1-Trifluoromethyl-1-cyclopropanecarbonyl chloride; (1-(Trifluoromethyl)cyclopropyl)carbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 1-(Trifluoromethyl)Cyclopropanecarbonyl Chloride adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your synthetic workflows. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.