Description

Ro4929097 CAS NO 847925-91-1 is a potent and selective small-molecule inhibitor of the γ-secretase enzyme complex. This compound is a critical research tool for investigating the Notch signaling pathway, which plays a fundamental role in cell differentiation, proliferation, and apoptosis. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, neurology, and developmental biology studies.

Application

• Notch Pathway Research: Fundamental tool for studying the role of Notch signaling in various biological processes and disease models.
• Oncology Research: Investigation of Notch inhibition as a potential therapeutic strategy for cancers where the pathway is dysregulated (e.g., T-cell acute lymphoblastic leukemia, breast cancer).
• Neurological Disease Models: Used in preclinical research for Alzheimer's disease, cerebral ischemia, and other conditions where γ-secretase activity is implicated.
• Stem Cell & Developmental Biology: Applied to modulate cell fate decisions and differentiation in stem cell cultures and developmental studies.
• Drug Discovery & Screening: Serves as a reference compound and positive control in high-throughput screening assays targeting γ-secretase.
• Biochemical & Cellular Assays: Used to validate assay systems and probe γ-secretase function and inhibitor mechanisms of action.

Basic Information

Item	Details
Product Name	Ro4929097
CAS No.	847925-91-1
Molecular Formula	C23H22F3N3O4
Molecular Weight	461.43 g/mol
Synonyms	RO4929097; RO-4929097; N-[4-(2,4-Difluorophenyl)-1,1-dimethyl-2-oxo-6-(trifluoromethyl)-1,2-dihydroquinolin-3-yl]-4-(dimethylamino)butanamide; γ-secretase inhibitor RO4929097; (R)-N1-((S)-2,3-Dihydroxypropyl)-N4-(3-(trifluoromethyl)benzyl)succinamide (Note: This is a common mis-assignment; verify structure); GSI RO4929097; Notch inhibitor RO4929097
EINECS	Contact for details

Quality Control

Our Ro4929097 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and LC-MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.