Description

5-Iodo-2'-o-Methylcytidine is a modified nucleoside analog of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a critical building block for the synthesis of oligonucleotides with enhanced stability and specific functionality. It is primarily utilized by researchers and manufacturers in the fields of antisense therapy, diagnostic probe development, and medicinal chemistry. The precise modification at the 2' position offers unique properties for tuning RNA interactions and metabolic stability.

Application

• Antisense Oligonucleotide (ASO) Synthesis: Key monomer for constructing oligonucleotides that modulate gene expression for therapeutic applications.
• Diagnostic Probe Development: Used in the creation of labeled probes for detecting specific RNA sequences in research and clinical diagnostics.
• Medicinal Chemistry & Drug Discovery: A vital intermediate in the research and development of novel nucleoside-based antiviral and anticancer agents.
• Structural Biology Studies: Employed to investigate RNA structure, function, and protein-RNA interactions due to its modified sugar moiety.
• siRNA and miRNA Research: Incorporated into synthetic RNA strands to enhance nuclease resistance and study RNA interference pathways.
• Bioconjugation and Labeling: The iodine atom provides a handle for further chemical modifications, such as radiolabeling or attachment of fluorophores.

Basic Information

Product Name	5-Iodo-2'-o-Methylcytidine
CAS No.	847650-69-5
Molecular Formula	C10H14IN3O5
Molecular Weight	383.14 g/mol
Synonyms	5-Iodo-2'-O-methylcytidine; 2'-O-Methyl-5-iodocytidine; 5-Iodo-2'-OMe-Cytidine; 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl)-5-iodopyrimidine-2,4-dione; 5-I-2'-OMe-C; 5-Iodo-2'-O-methyl-cytidine; 2'-O-Methyl-5-iodo-cytidine; 5-Iodo-2'-O-methylcytidine (847650-69-5)
EINECS	Contact for details

Quality Control

Our 5-Iodo-2'-o-Methylcytidine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. We provide Certificates of Analysis (COA) with each shipment, detailing all relevant specifications to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.