Description

8-Bromo-3'-Deoxyguanosine is a modified nucleoside analog, a crucial building block in oligonucleotide synthesis and medicinal chemistry research. This compound is specifically engineered to introduce bromine at the 8-position of the guanine base, which can serve as a versatile handle for further cross-coupling reactions or as a probe to study nucleic acid structure and function. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, antisense oligonucleotide (ASO) synthesis, and biochemical research.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA/RNA strands, enabling the site-specific incorporation of a bromine functional group.
• Medicinal Chemistry & Drug Discovery: Used in the development of nucleoside-based prodrugs and antiviral/anticancer agents, where the bromine moiety allows for further chemical diversification.
• Biochemical Probes: Acts as a substrate or inhibitor in enzymatic studies to investigate the mechanisms of polymerases, nucleotidyltransferases, and DNA repair enzymes.
• Structural Biology Studies: Incorporated into nucleic acids to study base-pairing dynamics, duplex stability, and to facilitate structure determination via X-ray crystallography.
• Cross-Coupling Reactions: The bromine atom serves as an excellent leaving group for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira), enabling postsynthetic modification of oligonucleotides.
• Antisense & siRNA Therapeutics: Used in the research and production of therapeutic oligonucleotides designed for gene silencing and targeted therapies.

Basic Information

Product Name	8-Bromo-3'-Deoxyguanosine
CAS No.	847649-68-7
Molecular Formula	C10H12BrN5O4
Molecular Weight	346.14 g/mol
Synonyms	8-Bromo-2'-deoxyguanosine; 8-Br-dG; 2'-Deoxy-8-bromoguanosine; 8-Bromodeoxyguanosine; 8-Bromo-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,9-dihydro-6H-purin-6-one; Guanosine, 2'-deoxy-8-bromo-; 8-Bromo-2'-deoxy-guanosine
EINECS	Contact for details

Quality Control

Our 8-Bromo-3'-Deoxyguanosine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Quality is verified by advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.