Description

8-Bromo-3'-Deoxy-3'-Fluoroguanosine is a chemically modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical synthetic intermediate and building block for the creation of novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions, pharmaceutical companies, and CROs engaged in the synthesis of modified oligonucleotides and nucleotide-based prodrugs. The structural modifications at the 3' and 8 positions make it a valuable precursor for probing biological mechanisms and developing targeted therapies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antiviral and anticancer nucleotide analogs.
• Antiviral Drug Research: Used in the development of potential therapeutics targeting viral polymerases and replication mechanisms.
• Oligonucleotide Synthesis: Serves as a modified monomer for incorporating specific functionalities into antisense oligonucleotides and siRNAs.
• Biochemical Probe Development: Utilized in research to study enzyme kinetics, nucleic acid interactions, and cellular uptake mechanisms.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Academic & Contract Research: Employed in university and CRO laboratories for fundamental research in nucleoside chemistry and biology.

Basic Information

Product Name	8-Bromo-3'-Deoxy-3'-Fluoroguanosine
CAS No.	847649-50-7
Molecular Formula	C10H11BrFN5O4
Molecular Weight	364.13 g/mol
Synonyms	8-Bromo-3'-deoxy-3'-fluoroguanosine; 8-Br-3'-F-dG; 8-Bromo-3'-fluoro-2',3'-dideoxyguanosine; Guanosine, 8-bromo-3'-deoxy-3'-fluoro-; 847649-50-7; 8-Bromo-3'-fluoro-2',3'-dideoxyguanosine; 8-Br-3'-F-Guo
EINECS	Contact for details

Quality Control

Our 8-Bromo-3'-Deoxy-3'-Fluoroguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports applications requiring high-purity, well-characterized chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccants and an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.