Description

4-Chloro-5-Iodo-7-(2-C-Methyl-β-D-Ribofuranosyl)-7H-Pyrrolo[2,3-D]Pyrimidine is a high-purity nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel antiviral and anticancer agents, particularly in the development of nucleoside-based therapeutics. It is essential for medicinal chemists and R&D teams in pharmaceutical, biotechnology, and fine chemical synthesis sectors seeking to develop targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel nucleoside analog drugs targeting viral infections and oncology.
• Antiviral Drug Research: Used in the R&D of potential therapeutics for hepatitis C virus (HCV) and other RNA viruses.
• Oncology Research: Serves as a precursor in the development of nucleoside-based chemotherapeutic agents and targeted cancer therapies.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and polymerase function.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4-Chloro-5-Iodo-7-(2-C-Methyl-β-D-Ribofuranosyl)-7H-Pyrrolo[2,3-D]Pyrimidine
CAS No.	847551-48-8
Molecular Formula	C12H13ClIN3O4
Molecular Weight	425.61 g/mol
Synonyms	2'-C-Methyl-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine ribonucleoside; 4-Chloro-5-iodo-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine; 7-(2-C-Methyl-β-D-ribofuranosyl)-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine; 4-Chloro-5-iodo-2'-C-methyl-7-deaza-adenosine; HCV Nucleoside Intermediate; 2'-C-Me-4-Cl-5-I-7-deaza-adenosine; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Iodo-7-(2-C-Methyl-β-D-Ribofuranosyl)-7H-Pyrrolo[2,3-D]Pyrimidine is manufactured under strict quality systems suitable for research and development use. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure consistent quality and batch-to-batch reproducibility. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.