Description

Benzoyl Chloride, 3,4-Difluoro-2-Methyl- CAS NO 847502-82-3 is a high-purity, fluorinated benzoyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine and methyl substituents on the aromatic ring, which allows for precise modulation of electronic and steric properties in target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated drug candidates, particularly for central nervous system (CNS) and anti-infective therapies.
• Agrochemical Synthesis: Used to create advanced fluorinated herbicides and pesticides, where the fluorine atoms improve lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorinated aromatic cores in electronic materials, enhancing charge transport and thermal stability.
• Polymer Modification: Employed to introduce benzoyl and fluorinated aromatic groups into polymer chains for specialty high-performance resins.
• Chemical Research & Development: A versatile reagent for introducing the 3,4-difluoro-2-methylbenzoyl moiety in medicinal chemistry and material science R&D.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of complex, fluorinated fine chemicals under cGMP conditions.

Basic Information

Product Name	Benzoyl Chloride, 3,4-Difluoro-2-Methyl-
CAS No.	847502-82-3
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	3,4-Difluoro-2-methylbenzoyl chloride; 2-Methyl-3,4-difluorobenzoyl chloride; 3,4-Difluoro-o-toluoyl chloride; Benzoyl chloride, 3,4-difluoro-2-methyl-; 847502-82-3; 3,4-Difluoro-2-methyl-benzoic acid chloride
EINECS	Contact for details

Quality Control

Every batch of 3,4-Difluoro-2-methylbenzoyl chloride is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the exacting standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, and NMR is supplied with each shipment. Our quality commitment supports compliance in cGMP and ISO-governed environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C (refrigerated) or as specified on the label. Due to its properties as a strong acid/organic solvent and being hygroscopic (moisture-sensitive) and highly volatile, it must be kept under an inert atmosphere (e.g., nitrogen or argon) and separated from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.