Description

o-(Methylthio)Methyl Triptolide is a chemically modified derivative of the natural diterpenoid triepoxide, triptolide, designed to enhance specific pharmacological properties and stability. This compound is of significant interest in advanced pharmaceutical research for its potential to modulate key biological pathways with improved selectivity. It is primarily utilized by research institutions and pharmaceutical developers focused on oncology, immunology, and inflammatory disease therapeutics. The product is supplied under stringent quality controls to ensure consistency for critical research and development applications.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic intermediate or precursor in the development of novel small-molecule therapeutics.
• Biomedical Research: Used as a reference standard or active probe in biochemical and cellular assays to study mechanisms of action related to its parent compound.
• Oncology Research: Investigated for its potential anti-proliferative and pro-apoptotic effects in various cancer cell line studies.
• Immunology & Autoimmune Disease Research: Explored for immunomodulatory properties in models of autoimmune and inflammatory conditions.
• Structure-Activity Relationship (SAR) Studies: Employed in medicinal chemistry programs to understand the impact of the o-(methylthio)methyl modification on potency and pharmacokinetics.
• High-Throughput Screening (HTS): Included in compound libraries for target identification and validation campaigns within drug discovery.

Basic Information

Product Name	o-(Methylthio)Methyl Triptolide
CAS No.	847440-49-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	o-(Methylthio)methyl Triptolide; (5R)-5-[(3aS,4S,6aS,7S,7aS)-7-Hydroxy-4,7a-dimethyl-2-oxo-3a,4,5,6,6a,7-hexahydro-1-benzofuran-4-yl]-3-methylidene-2-oxopentyl methyl sulfoxide (related structure); Triptolide Derivative; TPL Derivative; (Methylthio)Methyl Triptolide Analog
EINECS	Contact for details

Quality Control

Our o-(Methylthio)Methyl Triptolide is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.