Description

4-Chloro-3',4'-Difluorobenzhydrol is a high-purity fluorinated benzhydrol derivative, serving as a critical pharmaceutical intermediate and versatile building block in advanced organic synthesis. Its value lies in its unique molecular structure, which incorporates chlorine and fluorine substituents to modulate the reactivity and physicochemical properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, particularly for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the difluoro and chloro groups contribute to biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes (OLEDs) due to its impact on molecular polarity and alignment.
• Polymer Chemistry: Acts as a monomer or chain modifier in the production of specialty polymers with enhanced thermal and chemical resistance.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig aminations for constructing complex biaryl structures.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	4-Chloro-3',4'-Difluorobenzhydrol
CAS No.	844683-75-6
Molecular Formula	C13H9ClF2O
Molecular Weight	254.66 g/mol
Synonyms	[4-Chloro-3',4'-difluorobenzhydrol]; (4-Chlorophenyl)(3,4-difluorophenyl)methanol; Benzhydrol, 4-chloro-3',4'-difluoro-; 4-Chloro-α-(3,4-difluorophenyl)benzenemethanol; 1-(4-Chlorophenyl)-1-(3,4-difluorophenyl)methanol; (3,4-Difluorophenyl)(4-chlorophenyl)methanol; 4-Chloro-3',4'-difluorodiphenylmethanol
EINECS	Contact for details

Quality Control

Our 4-Chloro-3',4'-Difluorobenzhydrol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable, and our quality commitment ensures the material meets the stringent requirements for pharmaceutical R&D and commercial synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light), as indicated in its chemical properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.