Description

n-(3-(7-(1,3-Dimethyl-1H-Pyrazol-5-Ylamino)-1-Methyl-2-Oxo-1,2-Dihydropyrimido[4,5-D]Pyrimidin-3(4H)-Yl)-4-Methylphenyl)-3-(Trifluoromethyl)Benzamide is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of targeted therapeutic agents. Its complex heterocyclic structure, featuring a pyrimidopyrimidine core, makes it a critical building block for research and development in modern drug discovery. This compound is essential for medicinal chemists and pharmaceutical manufacturers focused on developing novel small-molecule inhibitors, particularly in oncology and other disease areas requiring precise molecular targeting.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the research and development of novel kinase inhibitors and other targeted cancer therapies.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Reagent: Used in high-throughput screening assays to identify and validate new biological targets and therapeutic pathways.
• Preclinical Development: Integral in the synthesis of candidate drug molecules for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Contract Manufacturing (CMO): Supplied to custom synthesis organizations for the cGMP production of active pharmaceutical ingredients (APIs) under development.
• Academic Research: Utilized in university and institutional labs for cutting-edge research in chemical biology and therapeutic agent design.

Basic Information

Product Name	n-(3-(7-(1,3-Dimethyl-1H-Pyrazol-5-Ylamino)-1-Methyl-2-Oxo-1,2-Dihydropyrimido[4,5-D]Pyrimidin-3(4H)-Yl)-4-Methylphenyl)-3-(Trifluoromethyl)Benzamide
CAS No.	839707-37-8
Molecular Formula	C28H24F3N7O2
Molecular Weight	547.53 g/mol
Synonyms	839707-37-8; Benzamide, N-[3-[7-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl]-4-methylphenyl]-3-(trifluoromethyl)-; UNII-1V8S2G2H8B; 1V8S2G2H8B; CS-0137966; AK-918/41228051; BDBM50389385; ZINC000003869756
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and reliability for critical R&D and scale-up processes. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment. We support development projects requiring compliance with ICH guidelines and can supply material suitable for preclinical and early-phase clinical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.