Description

(2S)-2-Acetamido-5-Oxo-5-Phosphonooxy-Pentanoic Acid is a high-purity, specialized phosphonic acid derivative of N-acetyl-L-glutamic acid. This compound is a critical building block and intermediate in advanced organic synthesis and pharmaceutical research, valued for its unique structural features that enable the study of enzyme inhibition and metabolic pathways. It is primarily utilized by research institutions, pharmaceutical development companies, and fine chemical manufacturers engaged in the creation of novel bioactive molecules and enzyme-targeted therapies.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of enzyme inhibitors, particularly targeting glutaminase and other phosphate-binding enzymes.
• Biochemical Research: Used as a substrate analog or inhibitor in enzymatic studies to investigate metabolic pathways involving glutamate and phosphate transfer.
• Proteomics & Chemical Biology: Employed in the design and synthesis of activity-based probes (ABPs) for labeling and studying specific enzyme families.
• Precision Medicinal Chemistry: Acts as a building block for constructing complex molecules with potential therapeutic applications in oncology and neurology.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	(2S)-2-Acetamido-5-Oxo-5-Phosphonooxy-Pentanoic Acid
CAS No.	837431-11-5
Molecular Formula	C7H12NO8P
Molecular Weight	269.15 g/mol
Synonyms	N-Acetyl-L-glutamic acid 5-phosphoric acid; 5-O-(Phosphonooxy)-N-acetyl-L-glutamic acid; L-Glutamic acid, N-acetyl-, 5-(dihydrogen phosphate); (2S)-2-Acetamido-5-(phosphonooxy)pentanedioic acid; Ac-Glu-5-P; N-Acetyl-L-glutamyl 5-phosphate; N-Acetyl-5-phosphonooxy-L-glutamic acid
EINECS	Contact for details

Quality Control

Every batch of (2S)-2-Acetamido-5-Oxo-5-Phosphonooxy-Pentanoic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.