Description

5-tert-Butyl-Thiophene-2-Carbonyl Chloride is a high-purity, reactive organic intermediate essential for advanced chemical synthesis. This compound matters as a key building block for introducing the tert-butyl-thiophene moiety into complex molecular architectures, enabling the development of novel materials and active compounds. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for creating new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the thiophene scaffold contributes to biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of advanced polymers, organic semiconductors, and conductive materials.
• Ligand and Catalyst Development: Employed to synthesize specialized ligands for metal-organic frameworks (MOFs) and catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target identification.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trials.

Basic Information

Product Name	5-tert-Butyl-Thiophene-2-Carbonyl Chloride
CAS No.	832113-93-6
Molecular Formula	C9H11ClOS
Molecular Weight	202.70 g/mol
Synonyms	2-(tert-Butyl)thiophene-5-carbonyl chloride; 5-tert-Butylthiophene-2-carboxylic acid chloride; 5-(1,1-Dimethylethyl)-2-thiophenecarbonyl chloride; 2-Thiophenecarbonyl chloride, 5-(1,1-dimethylethyl)-; 5-tert-Butyl-2-thiophenecarbonyl chloride; 5-tert-Butylthiophene-2-carbonyl chloride; 5-tert-Butyl-2-thienoyl chloride
EINECS	Contact for details

Quality Control

Our 5-tert-Butyl-Thiophene-2-Carbonyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to meet exacting customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.