Description

Pyrrolidine, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-5-methyl-, (2R,5R)-rel- is a chiral, silyl-protected pyrrolidine derivative of significant synthetic utility. This compound matters as a versatile and protected chiral building block, enabling the stereoselective construction of complex molecules in pharmaceutical and fine chemical synthesis. It is primarily needed by research chemists and process development scientists in the pharmaceutical industry for the development of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: Serves as a key precursor for the development of novel drug candidates, particularly in classes requiring pyrrolidine-based chiral centers.
• Building Block for Asymmetric Catalysis: Used in the preparation of chiral ligands or organocatalysts for stereoselective transformations.
• Research & Development of Bioactive Molecules: Employed in medicinal chemistry programs for the exploration of structure-activity relationships (SAR) in target-oriented synthesis.
• Synthesis of Natural Product Analogues: Facilitates the construction of complex natural product scaffolds and their synthetic derivatives.
• Process Chemistry & Scale-Up: Suitable for use in route development and optimization for the commercial-scale manufacturing of advanced intermediates.

Basic Information

Product Name	Pyrrolidine, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-5-methyl-, (2R,5R)-rel-
CAS No.	830335-26-7
Molecular Formula	C13H29NOSi
Molecular Weight	243.46 g/mol
Synonyms	rel-(2R,5R)-2-((tert-Butyldimethylsilyloxy)methyl)-5-methylpyrrolidine; 2-((tert-Butyldimethylsilyloxy)methyl)-5-methylpyrrolidine (racemic mixture of (2R,5R) and (2S,5S) enantiomers); TBDMS-protected 5-methyl-2-pyrrolidinemethanol; (2R,5R)-rel-2-(((tert-Butyldimethylsilyl)oxy)methyl)-5-methylpyrrolidine; 5-Methyl-2-pyrrolidinemethanol, 1-[(1,1-dimethylethyl)dimethylsilyl] ether, rel-(2R,5R)-; Chiral TBDMS-pyrrolidine building block
EINECS	Contact for details

Quality Control

Our Pyrrolidine, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-5-methyl-, (2R,5R)-rel- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure high chemical and stereochemical purity suitable for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99:1 dr (rel-(2R,5R) : rel-(2S,5S))
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.