Description

Adenosine, n-Acetyl-3',5'-o-[1,1,3,3-Tetrakis(1-Methylethyl)-1,3-Disiloxanediyl]- is a sophisticated, protected nucleoside derivative, specifically designed as a critical synthetic intermediate for advanced pharmaceutical research and development. Its core value lies in the strategic protection of the ribose hydroxyl groups with a bulky disiloxane moiety, which provides exceptional stability and selectivity during complex oligonucleotide and nucleotide synthesis. This compound is essential for researchers and manufacturers in the fields of antiviral drug development, oligonucleotide therapeutics (e.g., antisense, siRNA), and medicinal chemistry, where precise molecular construction is paramount.

Application

• Key Intermediate in Antiviral Prodrug Synthesis: Serves as a protected precursor in the manufacturing of nucleotide analogs used to treat viral infections like Hepatitis C (HCV) and others.
• Oligonucleotide & siRNA Production: Used in solid-phase and solution-phase synthesis to build modified RNA/DNA strands for therapeutic and diagnostic applications.
• Medicinal Chemistry & Lead Optimization: Enables the synthesis of novel adenosine receptor ligands and other bioactive nucleoside derivatives for drug discovery programs.
• Bioconjugation and Probe Development: Facilitates the creation of labeled nucleotides for imaging, diagnostics, and biochemical assays.
• Process Chemistry & Scale-Up: Provides a reliable, high-purity building block for the kilogram-scale production of active pharmaceutical ingredients (APIs).
• Academic Research: Supports cutting-edge studies in nucleic acid chemistry, enzymology, and molecular biology.

Basic Information

Item	Details
Product Name	Adenosine, n-Acetyl-3',5'-o-[1,1,3,3-Tetrakis(1-Methylethyl)-1,3-Disiloxanediyl]-
CAS No.	828247-65-0
Molecular Formula	C26H47N5O6Si2
Molecular Weight	589.86 g/mol
Synonyms	3',5'-O-(1,1,3,3-Tetraisopropyldisiloxane-1,3-diyl)-N-acetyladenosine; N-Acetyl-3',5'-O-(tetraisopropyldisiloxanyl)adenosine; TIPDS-protected N-acetyladenosine; N-Ac-Ado(TIPDS); 2'-Deoxy-N-acetyladenosine 3',5'-cyclic TIPDS ether; Adenosine, N-acetyl-, 3',5'-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl) derivative
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate is produced under strict quality management systems to ensure consistency and purity for sensitive synthetic applications. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with each shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep away from fluoride sources and strong alkali.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.