Description

Pd 0332991 Hcl is a high-purity, small molecule chemical compound used in advanced research and development. This compound is significant as a potent and selective inhibitor of cyclin-dependent kinases (CDKs), specifically targeting CDK4 and CDK6, which are critical regulators of the cell cycle. It is primarily needed by pharmaceutical researchers, biotechnology companies, and academic institutions engaged in oncology drug discovery, cancer biology studies, and the development of targeted cancer therapies.

Application

• Oncology Research & Drug Discovery: Serves as a key reference standard and active pharmaceutical ingredient (API) in the development of novel CDK4/6 inhibitor therapeutics for various cancers, including breast cancer.
• Biochemical Assay Development: Used as a precise tool compound to establish and validate in vitro kinase inhibition assays and cellular proliferation studies.
• Mechanism of Action Studies: Employed in preclinical research to investigate cell cycle arrest, senescence, and the role of the CDK4/6-Rb pathway in tumorigenesis.
• Pharmaceutical Intermediates: Acts as a critical synthetic intermediate in the scaled-up production of finished drug substances for clinical trials.
• Academic & Institutional Research: Utilized in university and research institute laboratories for fundamental cancer biology and signal transduction pathway analysis.

Basic Information

Product Name	Pd 0332991 Hcl
CAS No.	827022-32-2
Molecular Formula	C23H27FN4O2 • HCl
Molecular Weight	446.95 g/mol (Free base: 410.49)
Synonyms	Palbociclib Hydrochloride; PD-0332991 Hydrochloride; PD-0332991 HCl; Ibrance (brand name reference); 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride; (S)-6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-8H-pyrido[2,3-d]pyrimidin-7-one hydrochloride
EINECS	Contact for details

Quality Control

Our Pd 0332991 Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, residual solvent testing, and identity confirmation via spectroscopic methods, to ensure it meets stringent standards for research and development use. Certificates of Analysis (COA) with detailed chromatograms and full analytical data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C, in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and may require desiccant for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0% (anhydrous basis)
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.