Description

5'-o-(4,4'-Dimethoxytrityl)-5-Methyl-2,2'-Anhydro-D-Uridine is a key, high-purity nucleoside derivative used as a critical building block in the synthesis of modified oligonucleotides. Its primary value lies in enabling the precise incorporation of 5-methyluridine analogs, which are essential for enhancing the stability and biological activity of therapeutic nucleic acids. This compound is indispensable for research and development teams in the pharmaceutical and biotechnology sectors, particularly those focused on antisense oligonucleotides, siRNA, and other advanced nucleic acid therapeutics.

Application

• Oligonucleotide Synthesis: A vital phosphoramidite precursor for the solid-phase synthesis of RNA and DNA strands containing 5-methyluridine modifications.
• Antisense Drug Development: Used in the manufacture of antisense oligonucleotides (ASOs) where methylation improves nuclease resistance and target binding affinity.
• siRNA and miRNA Research: Critical for producing small interfering RNA (siRNA) and microRNA (miRNA) analogs with enhanced stability and silencing efficiency.
• Therapeutic Aptamer Production: Employed in creating chemically modified aptamers for diagnostic and therapeutic applications.
• Biochemical Research: Serves as a standard and reagent in studies investigating RNA structure, function, and metabolism.
• Process Development & Scale-up: Used by CDMOs and pharmaceutical companies for process optimization and GMP-grade production of nucleic acid APIs.

Basic Information

Product Name	5'-o-(4,4'-Dimethoxytrityl)-5-Methyl-2,2'-Anhydro-D-Uridine
CAS No.	817623-11-3
Molecular Formula	C31H30N2O7
Molecular Weight	542.58 g/mol
Synonyms	5'-O-DMT-5-methyl-2,2'-anhydro-uridine; 5-Methyl-2,2'-anhydro-1-(5-O-[(4,4-dimethoxytriphenyl)methyl]-β-D-ribofuranosyl)uracil; 5'-O-(4,4'-Dimethoxytrityl)-5-methyl-2,2'-anhydrouridine; DMT-5-Me-2,2'-anhydroU; 5-Methyl-2,2'-anhydro-5'-O-DMT-uridine; 5'-O-DMT-5-methyl-2,2'-anhydro-D-uridine
EINECS	Contact for details

Quality Control

Our 5'-o-(4,4'-Dimethoxytrityl)-5-Methyl-2,2'-Anhydro-D-Uridine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our customers' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.