Description

Apatinib is a potent and selective small-molecule inhibitor targeting vascular endothelial growth factor receptor-2 (VEGFR-2). This compound is a critical research tool and active pharmaceutical ingredient (API) for the development of novel anti-angiogenic cancer therapies. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract manufacturing organizations (CMOs) engaged in oncology drug discovery and development.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in the preclinical and clinical development of targeted cancer therapeutics.
• Oncology Drug Discovery: Used as a potent VEGFR-2 inhibitor in biochemical and cellular assays to study angiogenesis pathways and screen for synergistic drug combinations.
• Academic & Biomedical Research: Employed in university and institutional labs to investigate tumor biology, metastasis, and the mechanisms of anti-angiogenic therapy resistance.
• Chemical Synthesis Intermediates: Acts as a sophisticated building block for medicinal chemists synthesizing novel analogs or prodrugs for structure-activity relationship (SAR) studies.
• GMP Manufacturing: Supplied as a high-purity intermediate or API for cGMP-compliant manufacturing of investigational new drugs (INDs) and finished dosage forms.

Basic Information

Product Name	Apatinib
CAS No.	811803-05-1
Molecular Formula	C24H23N5O
Molecular Weight	397.47 g/mol
Synonyms	YN968D1; Apatinib Mesylate; Rivoceranib; 1-(4-(1-Cyanocyclopentyl)phenyl)-5-(4-pyridinyl)-1H-pyrazole-3-carboxamide; N-[4-(1-Cyanocyclopentyl)phenyl]-5-pyridin-4-yl-1H-pyrazole-3-carboxamide
EINECS	Contact for details

Quality Control

Our Apatinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation via spectroscopic methods (IR, NMR, MS). We provide full traceability and Certificates of Analysis (COA) that detail all specifications and test results, ensuring compliance with research and cGMP-grade requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which may affect stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.