Description

5'-Carboxy-2',3'-o-Isopropylideneadenosine is a key protected nucleoside derivative, serving as a crucial synthetic intermediate in modern organic and medicinal chemistry. Its value lies in the strategic protection of the ribose diol, which allows for selective functionalization at the 5'-position, enabling the synthesis of complex nucleotide analogs. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing novel antiviral agents, anticancer therapeutics, and advanced oligonucleotide-based drugs.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of nucleoside-based antiviral and anticancer drugs.
• Oligonucleotide Synthesis: Used in the preparation of modified oligonucleotides for research, diagnostics, and therapeutic applications.
• Prodrug Development: Serves as a precursor for creating prodrugs with improved bioavailability and targeted delivery.
• Bioconjugation Chemistry: The carboxylic acid group enables conjugation to peptides, proteins, or other molecules for creating targeted bioconjugates.
• Chemical Biology Research: Employed in the study of enzyme mechanisms and the development of molecular probes.
• Nucleotide Analog Library Synthesis: A versatile starting material for generating diverse libraries of nucleotide analogs for high-throughput screening.

Basic Information

Product Name	5'-Carboxy-2',3'-o-Isopropylideneadenosine
CAS No.	811431-33-1
Molecular Formula	C14H17N5O6
Molecular Weight	351.32 g/mol
Synonyms	Adenosine, 5'-carboxy-2',3'-O-(1-methylethylidene)-; 2',3'-O-Isopropylideneadenosine-5'-carboxylic Acid; 5'-Carboxy-2',3'-O-isopropylideneadenosine; 5'-Carboxy-2',3'-O-(1-methylethylidene)adenosine; N6-Adenosine-5'-carboxylic acid, 2',3'-O-isopropylidene-; Protected Adenosine-5'-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 5'-Carboxy-2',3'-o-Isopropylideneadenosine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.