Description

((3Ar,6S,6As)-6-(6-Amino-9H-Purin-9-Yl)-5-Fluoro-2,2-Dimethyl-6,6A-Dihydro-3Ah-Cyclopenta[D][1,3]Dioxol-4-Yl)Methanol CAS NO 805245-45-8 is a high-purity, advanced pharmaceutical intermediate characterized by its complex nucleoside-like structure. This compound is of critical importance for its role as a key building block in the synthesis of novel antiviral and anticancer therapeutics, particularly those targeting viral polymerases. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of next-generation nucleotide analogs and prodrugs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel antiviral drugs, especially for hepatitis and other viral infections.
• Anticancer Drug Research: Used in the R&D of nucleotide-based chemotherapeutic agents and targeted cancer therapies.
• Prodrug Synthesis: A key starting material for creating prodrugs designed to improve bioavailability and targeted delivery of active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate polymerase mechanisms and inhibition.
• Process Chemistry & Scale-Up: Utilized in process development and optimization for the commercial manufacturing of complex active molecules.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	((3Ar,6S,6As)-6-(6-Amino-9H-Purin-9-Yl)-5-Fluoro-2,2-Dimethyl-6,6A-Dihydro-3Ah-Cyclopenta[D][1,3]Dioxol-4-Yl)Methanol
CAS No.	805245-45-8
Molecular Formula	C15H18FN5O3
Molecular Weight	335.33 g/mol
Synonyms	9-[(1S,4R,5R)-4-(Hydroxymethyl)-2,2-dimethyl-3,6-dioxabicyclo[3.1.0]hex-5-yl]-5-fluoro-9H-purin-6-amine; 5-Fluoro-9-[(1S,4R,5R)-4-(hydroxymethyl)-2,2-dimethyl-3,6-dioxabicyclo[3.1.0]hex-5-yl]-9H-purin-6-amine; 5-Fluoro-9-(4-hydroxymethyl-2,2-dimethyl-3,6-dioxabicyclo[3.1.0]hex-5-yl)adenine; Bicyclic Nucleoside Intermediate; 805245-45-8 (CAS)
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up processes. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. We support compliance with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which may affect stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.