Description

Obatoclax Mesilate is a potent, cell-permeable small molecule inhibitor of the Bcl-2 family of anti-apoptotic proteins. This compound is a critical research tool and pharmaceutical intermediate for developing novel cancer therapeutics that overcome treatment resistance. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on oncology and apoptosis pathway studies.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel anti-cancer drug candidates targeting apoptosis pathways.
• Biochemical Research: Used as a reference standard and active agent in in vitro and in vivo studies to investigate Bcl-2 protein family function and inhibition.
• Oncology Drug Discovery: Serves as a lead compound or pharmacophore model for designing next-generation pro-apoptotic agents for hematologic and solid tumors.
• Mechanistic Studies: Employed to study mechanisms of chemotherapy resistance and to develop combination therapies that sensitize cancer cells to treatment.
• Preclinical Development: Used in formulation studies, pharmacokinetic/pharmacodynamic (PK/PD) modeling, and toxicology assessments for investigational new drugs (INDs).

Basic Information

Product Name	Obatoclax Mesilate
CAS No.	803712-79-0
Molecular Formula	C₂₀H₁₉N₃O₃S • CH₄O₃S
Molecular Weight	477.56 g/mol
Synonyms	Obatoclax Mesylate; GX15-070 Mesylate; GX15-070MS; (Z)-1,3-Dihydro-1-(1H-pyrrol-2-ylmethylene)-5-(1H-pyrrol-2-yl)-2H-indol-2-one methanesulfonate; 1H-Pyrrole, 2,2'-(2-oxo-1,3-dihydro-2H-indol-1-ylidene)bis-, methanesulfonate (1:1); GX 15-070 Mesilate; Obatoclax Methanesulfonate
EINECS	Contact for details

Quality Control

Our Obatoclax Mesilate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	Yellow to orange solid powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.