Description

Butyl Itraconazole is a potent triazole antifungal agent, specifically a derivative of itraconazole designed for enhanced formulation stability and bioavailability. This compound is critical for developing advanced pharmaceutical and agrochemical products requiring reliable and long-lasting antifungal activity. It serves as a key intermediate and active ingredient for manufacturers in the pharmaceutical, veterinary medicine, and specialty agrochemical sectors seeking to combat a broad spectrum of fungal pathogens.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of advanced antifungal drug formulations and prodrugs.
• Veterinary Medicine: Incorporated into topical and systemic treatments for fungal infections in livestock and companion animals.
• Agrochemicals: Used in the development of high-efficacy fungicides for crop protection.
• Research & Development: Serves as a reference standard and building block in microbiological and pharmacological research.
• Personal Care: Potential application in antifungal creams and lotions for dermal use.
• Material Preservation: Investigated for use in coatings and polymers to impart antifungal properties.

Basic Information

Product Name	Butyl Itraconazole
CAS No.	89848-51-1
Molecular Formula	C35H38Cl2N8O4
Molecular Weight	705.63 g/mol
Synonyms	Butyl Itraconazole; 4-Butyl-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one derivative of Itraconazole; Itraconazole Butyl Derivative; (2R,4S)-rel-2-Butyl-4-[[4-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one; R 51211 Butyl Derivative
EINECS	Contact for details

Quality Control

Our Butyl Itraconazole is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by IR and NMR spectroscopy, to ensure it meets stringent specifications. Certificates of Analysis (COA) are provided with every shipment, documenting compliance with agreed-upon standards. We support cGMP and ISO guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.