Description

5-(2-Hydroxyethyl)-Cytosine is a modified nucleobase derivative of cytosine, featuring a hydroxylethyl side chain that imparts unique chemical reactivity and solubility properties. This compound is a crucial building block and intermediate in the synthesis of novel nucleoside analogs and oligonucleotides, enabling advanced research and development. It is primarily sought after by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on antiviral drug discovery, nucleic acid chemistry, and the development of molecular probes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used as a modified base for creating specialized DNA/RNA sequences with enhanced properties for research and diagnostics.
• Biochemical Research: Serves as a tool compound for studying enzyme mechanisms, such as those involving cytidine deaminases and other nucleoside-metabolizing enzymes.
• Prodrug Development: The hydroxylethyl group can be utilized for conjugation, aiding in the design of prodrugs with improved bioavailability.
• Molecular Probe Synthesis: Acts as a scaffold for creating labeled nucleotides used in imaging and diagnostic assays.
• Chemical Biology: Employed in the development of chemical libraries for high-throughput screening against biological targets.

Basic Information

Product Name	5-(2-Hydroxyethyl)-Cytosine
CAS No.	89711-99-9
Molecular Formula	C7H11N3O2
Molecular Weight	169.18 g/mol
Synonyms	5-(2-Hydroxyethyl)cytosine; N4-Hydroxyethylcytosine; 2(1H)-Pyrimidinone, 4-amino-5-(2-hydroxyethyl)-; 4-Amino-5-(2-hydroxyethyl)-2(1H)-pyrimidinone; Cytosine, 5-(2-hydroxyethyl)-; 5-(β-Hydroxyethyl)cytosine; 5-Hydroxyethylcytosine
EINECS	Contact for details

Quality Control

Our 5-(2-Hydroxyethyl)-Cytosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) to ensure traceability and compliance with your research or production standards. Custom purity grades, including research and pharmaceutical intermediate specifications, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.