Description

1H-Imidazole-4-Carbonyl Chloride, 2,5-Difluoro- (9Ci) is a high-value, multi-functional heterocyclic building block, specifically an acid chloride derivative of a difluorinated imidazole. Its primary value lies in its reactivity as an acylating agent, enabling the efficient synthesis of amides and esters for advanced chemical synthesis. This compound is particularly relevant for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it serves as a key intermediate in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and other biologically active molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluorinated imidazole core can impart favorable metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for functionalized polymers, ligands for catalysis, and other specialty materials requiring a reactive imidazole moiety.
• Chemical Biology & Proteomics: Employed as a reagent for protein labeling, bioconjugation, and the development of chemical probes due to its selective reactivity with amines.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1H-Imidazole-4-Carbonyl Chloride, 2,5-Difluoro- (9Ci)
CAS No.	89676-64-2
Molecular Formula	C4H2ClF2N2O
Molecular Weight	176.52 g/mol
Synonyms	2,5-Difluoro-1H-imidazole-4-carbonyl chloride; 2,5-Difluoroimidazole-4-carbonyl chloride; 4-(Chlorocarbonyl)-2,5-difluoro-1H-imidazole; 2,5-Difluoro-1H-imidazole-4-carboxylic acid chloride; 2,5-Difluoroimidazole-4-carboxylic acid chloride; 89676-64-2 (CAS)
EINECS	Contact for details

Quality Control

Our 1H-Imidazole-4-Carbonyl Chloride, 2,5-Difluoro- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.