Description

tert-Butyl n-(4-Isothiocyanatophenyl)Carbamate is a versatile and high-value chemical intermediate featuring both a protected amine and a reactive isothiocyanate group. This bifunctional nature makes it a critical building block for the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the life sciences sector for creating novel therapeutic agents and advanced biochemical probes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of small-molecule drug candidates, especially those targeting specific protein receptors.
• Bioconjugation Reagent: Used to label proteins, antibodies, or peptides via reaction with primary amines, creating stable thiourea linkages for diagnostics and imaging.
• Chemical Biology Probe Development: Serves as a scaffold for creating activity-based probes (ABPs) to study enzyme function and mechanism.
• Peptidomimetic Synthesis: Integral for constructing modified peptide backbones and non-natural amino acid derivatives with enhanced stability or activity.
• Material Science Research: Employed in the surface functionalization of polymers and nanoparticles for specialized applications.
• Agrochemical Intermediate: Potential use in the development of novel active ingredients for crop protection.

Basic Information

Product Name	tert-Butyl n-(4-Isothiocyanatophenyl)Carbamate
CAS No.	89631-75-4
Molecular Formula	C12H14N2O2S
Molecular Weight	250.32 g/mol
Synonyms	4-(tert-Butoxycarbonylamino)phenyl isothiocyanate; Boc-4-Aminophenyl Isothiocyanate; N-Boc-4-Aminophenyl Isothiocyanate; 1-(tert-Butoxycarbonyl)-4-isothiocyanatobenzene; tert-Butyl (4-isothiocyanatophenyl)carbamate; 4-Isothiocyanatophenyl carbamic acid tert-butyl ester; Boc-Phe(NCS)-OH (common abbreviation); N-(tert-Butoxycarbonyl)-4-isothiocyanatoaniline
EINECS	Contact for details

Quality Control

Our tert-Butyl n-(4-Isothiocyanatophenyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.