Description

2-(Trifluoromethyl)Phenyl Isothiocyanate is a specialized aromatic isothiocyanate derivative characterized by the presence of a reactive isothiocyanate (-N=C=S) group and a strongly electron-withdrawing trifluoromethyl substituent. This unique structure makes it a valuable high-purity building block for synthesizing advanced chemical intermediates, particularly in the development of heterocyclic compounds and functional materials. It is primarily sought after by pharmaceutical R&D teams, agrochemical scientists, and researchers in material science for creating novel active ingredients and ligands.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of thiourea derivatives and heterocyclic scaffolds with potential biological activity.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the stability imparted by the CF3 group.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of monomers or additives for advanced polymers and functional materials.
• Chemical Biology Probe: Useful for modifying proteins or other biomolecules due to the reactivity of the isothiocyanate group with amines.
• Custom Synthesis Building Block: Provides a versatile handle for medicinal and process chemistry to introduce the (trifluoromethyl)phenyl moiety into target molecules.

Basic Information

Product Name	2-(Trifluoromethyl)Phenyl Isothiocyanate
CAS No.	1743-86-8
Molecular Formula	C8H4F3NS
Molecular Weight	203.19 g/mol
Synonyms	1-Isothiocyanato-2-(trifluoromethyl)benzene; α,α,α-Trifluoro-o-tolyl Isothiocyanate; o-(Trifluoromethyl)phenyl Isothiocyanate; 2-Trifluoromethylphenyl Isothiocyanate; (2-Trifluoromethylphenyl) Isothiocyanate; 2-(Trifluoromethyl)benzenisothiocyanate; Isothiocyanic Acid 2-(Trifluoromethyl)phenyl Ester
EINECS	217-115-7

Quality Control

Our 2-(Trifluoromethyl)Phenyl Isothiocyanate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, GC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP and ISO standards for production, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as amines, alcohols, and oxidizing agents. The container must be kept tightly closed in a dry and inert atmosphere to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.