Description

4-(Boc-Aminomethyl)Phenyl Isothiocyanate is a specialized bifunctional chemical building block that combines a protected amine group with a reactive isothiocyanate moiety. This molecular architecture is critical for the controlled synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the life sciences industry for constructing targeted drug candidates and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key reagent for the synthesis of small molecule drug candidates, particularly in oncology and CNS therapeutic areas.
• Peptide Mimetic Synthesis: Used to introduce thiourea linkages, creating stable peptide analogs and mimetics for biological evaluation.
• Bioconjugation: Enables the site-specific labeling of proteins, antibodies, or other biomolecules via reaction with primary amines.
• Chemical Probe Development: Serves as a building block for creating activity-based probes (ABPs) used in chemical biology and proteomics research.
• Material Science: Can be incorporated into polymer backbones or surface coatings to introduce specific functional groups.
• Library Synthesis: Employed in combinatorial and parallel synthesis for generating diverse compound libraries for high-throughput screening.

Basic Information

Product Name	4-(Boc-Aminomethyl)Phenyl Isothiocyanate
CAS No.	89631-74-3
Molecular Formula	C13H16N2O2S
Molecular Weight	264.34 g/mol
Synonyms	1-[(1,1-Dimethylethoxy)carbonyl]amino]methyl]-4-isothiocyanatobenzene; 4-[[(tert-Butoxycarbonyl)amino]methyl]phenyl isothiocyanate; N-Boc-4-aminomethylphenyl isothiocyanate; tert-Butyl N-[(4-isothiocyanatophenyl)methyl]carbamate; 4-(Boc-aminomethyl)phenyl isothiocyanate; BOC-PMITC; 4-(N-Boc-aminomethyl)phenyl isothiocyanate
EINECS	Contact for details

Quality Control

Our 4-(Boc-Aminomethyl)Phenyl Isothiocyanate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.