Description

2-Hydroxy-4’-(Trifluoromethyl)Acetophenone is a specialized aromatic ketone derivative characterized by its hydroxyl and trifluoromethyl substituents, which confer unique electronic and steric properties. This compound is a valuable pharmaceutical intermediate and building block in advanced organic synthesis, prized for its role in modulating the biological activity and physicochemical characteristics of target molecules. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethylated aromatic scaffold for enhanced metabolic stability and lipophilicity.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve biological activity and environmental persistence.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions and asymmetric synthesis.
• Material Science Research: Employed in the development of advanced organic materials, including liquid crystals and polymers with specific optical or electronic properties.
• Chemical Research & Development: A versatile starting material for exploring novel organic reactions and creating compound libraries for high-throughput screening.

Basic Information

Product Name	2-Hydroxy-4’-(Trifluoromethyl)Acetophenone
CAS No.	89630-28-4
Molecular Formula	C9H7F3O2
Molecular Weight	204.15 g/mol
Synonyms	1-(2-Hydroxy-4-(trifluoromethyl)phenyl)ethan-1-one; 2'-Hydroxy-4'-(trifluoromethyl)acetophenone; 2-Hydroxy-α,α,α-trifluoro-p-acetophenone; 4'-Trifluoromethyl-2-hydroxyacetophenone; 1-[2-Hydroxy-4-(trifluoromethyl)phenyl]ethanone; 2-Hydroxy-4-trifluoromethylacetophenone; p-Trifluoromethyl-2-hydroxyacetophenone
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-4’-(Trifluoromethyl)Acetophenone is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material is suitable for demanding applications in GMP-aligned synthesis and research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.