Description

2'-Tbdms-Ibu-Rg CAS NO 89494-39-3 is a key protected intermediate in organic synthesis, specifically designed for the construction of complex pharmaceutical molecules. Its value lies in providing a robust and selective protecting group strategy, enabling precise synthetic routes and improving overall yield and purity in critical steps. This compound is essential for research chemists and process development scientists in the pharmaceutical and biotechnology industries, particularly those focused on developing new active pharmaceutical ingredients (APIs) and nucleotide analogs.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel therapeutic agents, especially in nucleotide and nucleoside chemistry.
• Antiviral Drug Research: Used in the development and scale-up of antiviral compounds, where precise protection of reactive hydroxyl groups is required.
• Oligonucleotide Synthesis: Serves as a protected monomer or precursor in the solid-phase synthesis of oligonucleotides for research and therapeutic applications.
• Process Chemistry: Employed in route scouting and optimization for the commercial manufacturing of complex small-molecule drugs.
• Medicinal Chemistry: Facilitates structure-activity relationship (SAR) studies by allowing selective modification of molecular scaffolds.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	2'-Tbdms-Ibu-Rg
CAS No.	89494-39-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2'-O-(tert-Butyldimethylsilyl) Ibuprofen Ribonucleoside Guanosine Derivative; 2'-TBDMS Ibu-Rg; Ibuprofen 2'-TBDMS Riboguanosine; 2'-tert-Butyldimethylsilyl Ibuprofen-Rg; Protected Ibuprofen Nucleoside; 89494-39-3; tert-Butyldimethylsilyl Ibuprofen Guanosine Ester
EINECS	Contact for details

Quality Control

Our 2'-Tbdms-Ibu-Rg is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under inert atmosphere when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.