Description

Cyclobutane-1,2-Dicarbonyl Dichloride is a high-purity, reactive acid chloride derivative of cyclobutane-1,2-dicarboxylic acid. This compound serves as a critical bifunctional building block for introducing the constrained cyclobutane ring system into target molecules, enabling the synthesis of novel chemical entities with tailored properties. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring a rigid, four-membered carbocyclic scaffold for bioactivity modulation.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the cyclobutane ring can influence stability and biological activity.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for producing specialty polymers, resins, and high-performance materials with unique thermal or mechanical properties.
• Ligand & Catalyst Development: Employed in the preparation of chiral ligands and organometallic catalysts for asymmetric synthesis applications.
• Peptide Mimetics & Bioconjugation: Useful for creating conformationally restricted peptide analogs or for introducing reactive handles onto biomolecules.
• Organic Synthesis Reagent: A versatile reagent for amide and ester formation, as well as for Friedel-Crafts acylation reactions under controlled conditions.

Basic Information

Product Name	Cyclobutane-1,2-Dicarbonyl Dichloride
CAS No.	89380-29-0
Molecular Formula	C6H6Cl2O2
Molecular Weight	181.02 g/mol
Synonyms	1,2-Cyclobutanedicarbonyl Dichloride; Cyclobutane-1,2-dicarboxylic Acid Dichloride; 1,2-Cyclobutanedicarboxylic Acid Dichloride; Cyclobutane-1,2-dicarboxylic Dichloride; 89380-29-0; Cyclobutanedioyl Dichloride; 1,2-Dichlorocarbonylcyclobutane
EINECS	Contact for details

Quality Control

Our Cyclobutane-1,2-Dicarbonyl Dichloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic and reactive nature, the container should be kept under an inert atmosphere (e.g., nitrogen or argon) and protected from moisture. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.