Description

Dimethyl 2-((4R,5R)-5-((R)-2-(Benzyloxy)-1-Hydroxyethyl)-2,2-Dimethyl-1,3-Dioxolan-4-Yl)-2-Oxoethylphosphonate is a high-value, stereochemically defined phosphonate building block critical for advanced organic synthesis. This compound matters as a key chiral intermediate, enabling the precise construction of complex molecules with defined three-dimensional architecture. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), particularly in antiviral and anticancer research.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of nucleoside analogues and other complex bioactive molecules.
• Antiviral Drug Research: Used in the development of prodrugs and nucleotide-based therapeutics targeting viral polymerases.
• Anticancer Agent Development: Serves as a building block for novel chemotherapeutic candidates that interfere with cellular metabolism.
• Process Chemistry: Employed in scalable, asymmetric synthesis routes for the production of high-value fine chemicals.
• Academic & Industrial R&D: A valuable tool for medicinal chemists exploring structure-activity relationships (SAR) in drug discovery programs.
• Synthesis of Prodrugs: Its phosphonate moiety is instrumental in creating bioreversible, membrane-permeable prodrug forms of phosphate-containing drugs.

Basic Information

Product Name	Dimethyl 2-((4R,5R)-5-((R)-2-(Benzyloxy)-1-Hydroxyethyl)-2,2-Dimethyl-1,3-Dioxolan-4-Yl)-2-Oxoethylphosphonate
CAS No.	89291-71-4
Molecular Formula	C₁₉H₂₉O₈P
Molecular Weight	416.40 g/mol
Synonyms	Dimethyl (2R)-2-[(4R,5R)-5-[(1R)-2-(Benzyloxy)-1-hydroxyethyl]-2,2-dimethyl-1,3-dioxolan-4-yl]-2-oxoethylphosphonate; (R)-Dimethyl (2-((4R,5R)-5-((R)-2-(Benzyloxy)-1-hydroxyethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-oxoethyl)phosphonate; Benzyl (2R)-2-[(4R,5R)-5-[(1R)-2-(Dimethoxyphosphoryl)acetyl]-2,2-dimethyl-1,3-dioxolan-4-yl]-2-hydroxyethyl ether; A Chiral Phosphonate Acetonide Derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Dimethyl 2-((4R,5R)-5-((R)-2-(Benzyloxy)-1-Hydroxyethyl)-2,2-Dimethyl-1,3-Dioxolan-4-Yl)-2-Oxoethylphosphonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full chromatographic data are provided to guarantee identity, purity, and stereochemical integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is sensitive to strong alkali and should be kept separate from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.