Description

2-Bromo-2'-Deoxyadenosine is a halogenated nucleoside derivative of significant importance in medicinal chemistry and life science research. This compound serves as a versatile synthetic intermediate and a key building block for the development of nucleotide analogs. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and manufacturers of active pharmaceutical ingredients (APIs) for applications in antiviral and anticancer drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies involving DNA polymerases and other nucleotide-processing enzymes.
• Probe Development: Acts as a building block for creating fluorescent or radiolabeled nucleotide probes for diagnostic and imaging applications.
• Antisense Oligonucleotide Synthesis: Incorporated into oligonucleotide sequences to modulate stability, binding affinity, and biological activity.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore the impact of halogen substitution on drug potency and selectivity.
• Academic & Contract Research: Serves as a standard or custom reagent for universities and CROs conducting fundamental research in nucleic acid chemistry.

Basic Information

Product Name	2-Bromo-2'-Deoxyadenosine
CAS No.	89178-21-2
Molecular Formula	C10H12BrN5O3
Molecular Weight	330.14 g/mol
Synonyms	2-Bromo-2'-deoxyadenosine; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-bromo-9H-purin-6-amine; 2-Br-dA; 2-Bromo-deoxyadenosine; 2-Bromoadenine deoxyriboside; 2-Bromo-9-(2-deoxy-β-D-erythro-pentofuranosyl)adenine; 2-Bromoadenosine-2'-deoxyriboside
EINECS	Contact for details

Quality Control

Our 2-Bromo-2'-Deoxyadenosine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.