Description

2(1H)-Pyrimidinone, 4-Amino-1-(5-o-((3-Carboxypropoxy)Hydroxyphosphiny L)-β-D-Arabinofuranosyl)- is a sophisticated nucleoside analog with significant potential in advanced pharmaceutical research and development. This compound is valued for its role as a key synthetic intermediate or active pharmaceutical ingredient (API) precursor in the creation of novel antiviral and anticancer therapeutics. It is primarily sought after by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of nucleotide-based drugs. The product's complex structure underscores its application in cutting-edge medicinal chemistry.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of nucleotide analog antiviral agents.
• Antiviral Drug Research: Investigated for its potential activity and mechanism in targeting viral polymerases or reverse transcriptases.
• Oncology Research: Used in the development of chemotherapeutic agents that interfere with DNA synthesis in rapidly dividing cells.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism.
• Preclinical Development: Utilized in the formulation and testing stages of new drug candidates prior to clinical trials.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2(1H)-Pyrimidinone, 4-Amino-1-(5-o-((3-Carboxypropoxy)Hydroxyphosphiny L)-β-D-Arabinofuranosyl)-
CAS No.	89142-98-3
Molecular Formula	C13H19N4O9P
Molecular Weight	406.28 g/mol
Synonyms	4-Amino-1-(5-O-((3-carboxypropoxy)hydroxyphosphinyl)-β-D-arabinofuranosyl)-2(1H)-pyrimidinone; 4-Amino-1-[5-O-({hydroxy[(3-carboxypropoxy)phosphinoyl]}oxy)-β-D-arabinofuranosyl]-1,2-dihydropyrimidin-2-one; 1-(5-O-{[Hydroxy(3-carboxypropoxy)phosphoryl]oxy}-β-D-arabinofuranosyl)-4-aminopyrimidin-2(1H)-one; GS-9191 (developmental code); GS 9191; A phosphonated nucleoside analog. Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and reliability for research and development purposes. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each batch, documenting purity, identity, and relevant impurity profiles. We support compliance with cGMP guidelines for advanced pharmaceutical intermediates where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.