Description

5-(n-T-Butyloxycarbonylmethyl)-n-(Trifluoroacetyl) Aminomethyl)-2-Thiouridine is a sophisticated, protected nucleoside derivative of significant value in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate, enabling the precise construction and modification of oligonucleotides and other biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including antisense oligonucleotides and other nucleic acid-based modalities.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A key protected building block for the solid-phase or solution-phase synthesis of therapeutic oligonucleotides.
• siRNA and miRNA Research: Used in the preparation of modified RNA strands to enhance stability and efficacy in gene silencing applications.
• Medicinal Chemistry: Serves as a versatile intermediate for creating nucleoside analogs with potential antiviral or anticancer activity.
• Bioconjugation and Probe Development: The reactive handles allow for site-specific labeling or conjugation in diagnostic probe development.
• Process Chemistry & Scale-up: Supports the development of robust, scalable synthetic routes for GMP-grade active pharmaceutical ingredients (APIs).

Basic Information

Product Name	5-(n-T-Butyloxycarbonylmethyl)-n-(Trifluoroacetyl) Aminomethyl)-2-Thiouridine
CAS No.	89129-10-2
Molecular Formula	C18H24F3N3O8S
Molecular Weight	499.46 g/mol
Synonyms	2-Thiouridine, 5-[[[[(1,1-Dimethylethoxy)carbonyl]amino]methyl](trifluoroacetyl)amino]methyl]; 5-[(N-Boc-aminomethyl)-N-trifluoroacetylamino]methyl-2-thiouridine; 5-(Boc-aminomethyl)(trifluoroacetamido)methyl-2-thiouridine; BOC-Aminomethyl-TFA-aminomethyl-2-thiouridine; Protected 2-Thiouridine Derivative; Nucleoside Intermediate 89129-10-2
EINECS	Contact for details

Quality Control

Our production of this high-purity biochemical intermediate adheres to stringent quality protocols. Every batch is characterized and tested using advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development from research to commercial scale with quality systems designed to meet cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.