Description

5-(n-Methyl-n-Trifluoroacetyl-Aminomethyl)-2-Thiouridine is a specialized nucleoside derivative, a key building block in advanced oligonucleotide synthesis and pharmaceutical research. Its primary value lies in its role as a modified monomer for introducing specific functionalities into nucleic acid sequences, enabling the development of novel therapeutics and diagnostic probes. This high-purity intermediate is essential for researchers and manufacturers in the fields of antisense oligonucleotide (ASO) development, siRNA therapeutics, and diagnostic assay design, where precise chemical modification is critical for efficacy and stability.

Application

• Oligonucleotide Synthesis: A critical phosphoramidite precursor for the solid-phase synthesis of modified RNA and DNA strands.
• Therapeutic Development: Used in the research and production of antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) for targeted gene silencing therapies.
• Diagnostic Probes: Incorporation into nucleic acid probes to enhance binding affinity, specificity, and nuclease resistance for advanced molecular diagnostics.
• Biochemical Research: A tool compound for studying RNA structure, function, and protein-RNA interactions in academic and industrial R&D settings.
• Aptamer Development: Serves as a modified nucleotide in Systematic Evolution of Ligands by Exponential Enrichment (SELEX) processes to create novel aptamers with improved properties.

Basic Information

Item	Details
Product Name	5-(n-Methyl-n-Trifluoroacetyl-Aminomethyl)-2-Thiouridine
CAS No.	89128-99-4
Molecular Formula	C13H15F3N3O6S
Molecular Weight	398.33 g/mol
Synonyms	5-(N-Methyl-N-trifluoroacetamidomethyl)-2-thiouridine; 2-Thio-5-(N-methyl-N-trifluoroacetamidomethyl)uridine; 5-(Methyl(trifluoroacetyl)amino)methyl-2-thiouridine; 5-(N-Methyl-N-trifluoroacetylaminomethyl)-2-thiouridine; 2-Thiouridine, 5-[(methyl(trifluoroacetyl)amino)methyl]-; 5-MTFAM-2-thiouridine; MTFA-2-thioU; 89128-99-4
EINECS	Contact for details

Quality Control

Our 5-(n-Methyl-n-Trifluoroacetyl-Aminomethyl)-2-Thiouridine is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical and life science applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality control protocols are designed to support regulatory filings for drug development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.