Description

2-Chloroestradiol is a halogenated derivative of the natural hormone estradiol, distinguished by the introduction of a chlorine atom at the 2-position of the steroid nucleus. This structural modification significantly alters its biological activity and metabolic profile, making it a valuable research compound for studying estrogen receptor interactions and metabolic pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and specialty chemical manufacturers focused on endocrinology and steroid chemistry.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of novel steroidal compounds with targeted therapeutic profiles.
• Biochemical Research: Used as a tool compound to investigate the structure-activity relationships (SAR) of estrogen receptors and to probe metabolic enzymes involved in steroid hormone processing.
• Endocrinology Studies: Employed in laboratory studies to understand the effects of halogenated estrogens on hormonal signaling pathways and cellular responses.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories using techniques like HPLC and LC-MS.
• Specialty Chemical Synthesis: Used as a building block for the custom synthesis of more complex, research-focused steroid derivatives.

Basic Information

Product Name	2-Chloroestradiol
CAS No.	88847-87-4
Molecular Formula	C18H23ClO2
Molecular Weight	306.83 g/mol
Synonyms	2-Chloroestra-1,3,5(10)-triene-3,17β-diol; 2-Chloro-17β-estradiol; 2-Chloro-E2; Estra-1,3,5(10)-triene-3,17-diol, 2-chloro-, (17β)-; 2-Cl-estradiol
EINECS	Contact for details

Quality Control

Our 2-Chloroestradiol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by chromatographic techniques (HPLC). We provide Certificates of Analysis (COA) with detailed batch-specific results for all critical parameters, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled and stored accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.